Peptides & Peptide Synthesis Products

Fmoc-Arg(Pbf)-OH

Fmoc-Arg(Pbf)-OH

$17.00
$17.00
Fmoc-Arg(Pbf)-OH, Catalog No: 41002
Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran- 5-sulfonyl)-L-arginine, CAS: 154445-77-9, MW: 648.77, Formula: C34H40N4O7S
Catalog No: 41002
Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran- 5-sulfonyl)-L-arginine, CAS: 154445-77-9, MW: 648.77, Formula: C34H40N4O7S

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Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran- 5-sulfonyl)-L-arginine
Additional Information

Additional Information

Catalog Number 41002
CAS 154445-77-9
M.W. 648.77
Formula C34H40N4O7S
IUPAC Name (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
Synonym Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran- 5-sulfonyl)-L-arginine
Also Known As
  • (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
  • (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
  • (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylene]amino]-2-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]pentanoic acid
  • (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-benzofuran-5-yl)sulfonylamino]methylene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)valeric acid
  • 47349_FLUKA
  • Fmoc-Arg(Pbf)-OH
  • Nalpha-Fmoc-Nomega-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
  • Nalpha-Fmoc-Nomega-Pbf-L-arginine
  • F8916_SIGMA
InChIKey HNICLNKVURBTKV-NDEPHWFRSA-N
InChI InChI=1S/C34H40N4O7S/c1-19-20(2)30(21(3)26-17-34(4,5)45-29(19)26)46(42,43)38-32(35)36-16-10-15-28(31(39)40)37-33(41)44-18-27-24-13-8-6-11-22(24)23-12-7-9-14-25(23)27/h6-9,11-14,27-28H,10,15-18H2,1-5H3,(H,37,41)(H,39,40)(H3,35,36,38)/t28-/m0/s1
SMILES CC1=C2C(=C(C(=C1C)S(=O)(=O)NC(=NCCC[C@@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)N)C)CC(O2)(C)C
Cited Uses

Details

1. Murugan RN et al, "De Novo Design and Synthesis of Ultra-Short Peptidomimetic Antibiotics Having Dual Antimicrobial and Anti-Inflammatory Activities", PLoS ONE, 8(11) pp.e80025 ().
2. Scheinpflug K et al, "What Goes around Comes around-A Comparative Study of the Influence of Chemical Modifications on the Antimicrobial Properties of Small Cyclic Peptides", Pharmaceuticals, 6(9) pp.1130-1144 ().
3. Chen W et al, "The Structural and Energetic Basis of Carbohydrate Aromatic Packing Interactions in Proteins", Journal of the American Chemical Society, 135(26) pp.9877-9884 (2013 Jul 3).
4. Pag├Ęs JM et al, "New Peptide-Based Antimicrobials for Tackling Drug Resistance in Bacteria: Single-Cell Fluorescence Imaging", ACS Medicinal Chemistry Letters, 4(6) pp.556-559 ().
5. Wissner RF et al, "Labeling Proteins with Fluorophore/Thioamide FRET Pairs by Combining Unnatural Amino Acid Mutagenesis and Native Chemical Ligation", Journal of the American Chemical Society, 135(17) pp.6529-6540 (2013 May 1).
6. de Rond T et al, "Versatile synthesis of probes for high-throughput enzyme activity screening", Analytical and Bioanalytical Chemistry, 405(14) pp.4969-4973 (2013 May).
7. An S et al, "Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic", International Journal of Nanomedicine, 8() pp.821-834 (2013).
8. Markowska A et al, "Synthesis and Biological Activity of N-Sulfonyltripeptides with C-Terminal Arginine as Potential Serine Proteases Inhibitors", International Journal of Peptide Research and Therapeutics, 19() pp.191-198 (2013).
9. Kunys AR et al, "Specificity Profiling of Protein-Binding Domains Using One-Bead-One-Compound Peptide Libraries", Current protocols in chemical biology, 4(4) pp.331-355 (2012 Dec 1).
10. Wu X et al, "Inhibition of Ras-Effector Interaction by Cyclic Peptides", MedChemComm, 4(2) pp.378-382 (2013 Feb 1).
11. Reddy PA et al, "Synthesis of Hemopressin Peptides by Classical Solution Phase Fragment Condensation", International Journal of Peptides, 2012() pp.186034 (2012).
12. Chen PC et al, "DNA-Interactive Properties of Crotamine, a Cell-Penetrating Polypeptide and a Potential Drug Carrier", PLoS ONE, 7(11) pp.e48913 ().
13. Albada HB et al, "Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups", Beilstein Journal of Organic Chemistry, 8() pp.1753-1764 ().
14. Gunasekera S et al, "Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation", International Journal of Peptide Research and Therapeutics, 19(1) pp.43-54 (2013 Mar).
15. Spurr IB et al, "Small Molecule Inhibitor of AICAR Transformylase Homodimerization", Chembiochem : a European journal of chemical biology, 13(11) pp.1628-1634 (2012 Jul 23).
16. Tran DT et al, "Glycosylation of ?-Dystroglycan: O-MANNOSYLATION INFLUENCES THE SUBSEQUENT ADDITION OF GalNAc BY UDP-GalNAc POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASES", The Journal of Biological Chemistry, 287(25) pp.20967-20974 (2012 Jun 15).
17. Batjargal S et al, "Native Chemical Ligation of Thioamide-Containing Peptides: Development and Application to the Synthesis of Labeled ?-Synuclein for Misfolding Studies", Journal of the American Chemical Society, 134(22) pp.9172-9182 (2012 Jun 6).
18. Rothbart SB et al, "Peptide Microarrays to Interrogate the Histone Code", Methods in enzymology, 512() pp.107-135 (2012).
19. Cheng C et al, "Comparison between 68Ga-bombesin (68Ga-BZH3) and the cRGD tetramer 68Ga-RGD4 studies in an experimental nude rat model with a neuroendocrine pancreatic tumor cell line", EJNMMI Research, 1() pp.34 ().
20. Wiessler M et al, "Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy", Theranostics, 1() pp.381-394 ().
21. Nam HY et al, "Erythropoietin gene delivery using an arginine-grafted bioreducible polymer system", Journal of Controlled Release, 157(3) pp.437-444 (2012 Feb 10).
22. Dong S et al, "Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain", Israel journal of chemistry, 51(8-9) pp.968-976 (2011 Nov).
23. Brabez N et al, "Design, synthesis and biological studies of efficient multivalent melanotropin ligands: tools towards melanoma diagnosis and treatment", Journal of medicinal chemistry, 54(20) pp.7375-7384 (2011 Oct 27).
24. Mahto SK et al, "A Reversible Protection Strategy to Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach", Chembiochem : a European journal of chemical biology, 12(16) pp.2488-2494 (2011 Nov 4).
25. Kuester M et al, "Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors", Biological chemistry, 392(11) pp.973-981 (2011 Nov).
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