Peptides & Peptide Synthesis Products

Fmoc-Asp(OtBu)-OH

Fmoc-Asp(OtBu)-OH
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Fmoc-Asp(OtBu)-OH, Catalog No: 41019
Nα-Fmoc-L-aspartic acid 4-tert-butyl ester, CAS: 71989-14-5, MW: 411.45, Formula: C23H25NO6
Catalog No: 41019
Nα-Fmoc-L-aspartic acid 4-tert-butyl ester, CAS: 71989-14-5, MW: 411.45, Formula: C23H25NO6

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Description

Details

Nα-Fmoc-L-aspartic acid 4-tert-butyl ester
Additional Information

Additional Information

Catalog Number 41019
CAS 71989-14-5
M.W. 411.45
Formula C23H25NO6
IUPAC Name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
Synonym Nα-Fmoc-L-aspartic acid 4-tert-butyl ester
Also Known As
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
  • (2S)-4-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid
  • (2S)-4-tert-butoxy-2-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]-4-oxobutanoic acid
  • (2S)-4-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-keto-butyric acid
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-butanoic acid
  • ST5307352
  • Fmoc-Asp(OtBu)-OH
  • Fmoc-L-aspartic acid 4-tert-butyl ester
  • 47618_FLUKA
InChIKey FODJWPHPWBKDON-IBGZPJMESA-N
InChI InChI=1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1
SMILES CC(C)(C)OC(=O)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Cited Uses

Details

1. Pipkorn R et al, "A Peptide & Peptide Nucleic Acid Synthesis Technology for Transporter Molecules and Theranostics - The SPPS", International Journal of Medical Sciences, 11(7) pp.697-706 ().
2. Dębowski D et al, "Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1", PLoS ONE, 9(2) pp.e89465 ().
3. Wissner RF et al, "Labeling Proteins with Fluorophore/Thioamide FRET Pairs by Combining Unnatural Amino Acid Mutagenesis and Native Chemical Ligation", Journal of the American Chemical Society, 135(17) pp.6529-6540 (2013 May 1).
4. Gunasekera S et al, "Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation", International Journal of Peptide Research and Therapeutics, 19(1) pp.43-54 (2013 Mar).
5. Dong S et al, "Engineering of Therapeutic Polypeptides Through Chemical Synthesis: Early Lessons From Human Parathyroid Hormone and Analogs", Journal of the American Chemical Society, 134(36) pp.15122-15129 (2012 Sep 12).
6. Batjargal S et al, "Native Chemical Ligation of Thioamide-Containing Peptides: Development and Application to the Synthesis of Labeled ?-Synuclein for Misfolding Studies", Journal of the American Chemical Society, 134(22) pp.9172-9182 (2012 Jun 6).
7. Rothbart SB et al, "Peptide Microarrays to Interrogate the Histone Code", Methods in enzymology, 512() pp.107-135 (2012).
8. Dong S et al, "Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain", Israel journal of chemistry, 51(8-9) pp.968-976 (2011 Nov).
9. Lindhorst TK et al, "En route to photoaffinity labeling of the bacterial lectin FimH", Beilstein Journal of Organic Chemistry, 6() pp.810-822 ().
10. Jarvis A et al, "Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction", Journal of Medicinal Chemistry, 53(5) pp.2215-2226 (2010 Mar 11).
11. Peterson QP et al, "Preparation of the Caspase-3/-7 substrate Ac-DEVD-pNA via Solution-Phase Peptide Synthesis", Nature protocols, 5(2) pp.294-302 (2010).
12. Demon D et al, "Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity", Molecular & Cellular Proteomics : MCP, 8(12) pp.2700-2714 (2009 Dec).
13. Hong V et al, "Thiol-Selective Fluorogenic Probes for Labeling and Release", Journal of the American Chemical Society, 131(29) pp.9986-9994 (2009 Jul 29).
14. Jagasia R et al, "Peptide Cyclization and Cyclodimerization by CuI-Mediated Azide-Alkyne Cycloaddition", The Journal of organic chemistry, 74(8) pp.2964-2974 (2009 Apr 17).
15. Furbert P et al, "Label-Free Optical Detection of Peptide Synthesis on a Porous Silicon Scaffold/Sensor", Langmuir : the ACS journal of surfaces and colloids, 24(6) pp.2908-2915 (2008 Mar 18).
16. Kállay C et al, "Thermodynamic and Structural Characterization of the Copper(II) Complexes of Peptides Containing Both Histidyl and Aspartyl Residues", Bioinorganic Chemistry and Applications, 2007() pp.30394 (2007).
17. Mukhopadhyay S et al, "Conjugated Platinum(IV)-Peptide Complexes for Targeting Angiogenic Tumor Vasculature", Bioconjugate chemistry, 19(1) pp.39-49 (2008 Jan).
18. Yoo B et al, "Peptidyl Molecular Imaging Contrast Agents Using a New Solid Phase Peptide Synthesis Approach", Bioconjugate chemistry, 18(3) pp.903-911 (2007).
19. Kelly JA et al, "Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II", Biochemical Journal, 389(Pt 2) pp.569-576 (2005 Jul 15).
20. Gault VA et al, "Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.", Biochemical Journal, 367(Pt 3) pp.913-920 (2002 Nov 1).
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