Peptides & Peptide Synthesis Products

Fmoc-His(Trt)-OH

Fmoc-His(Trt)-OH

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Fmoc-His(Trt)-OH, Catalog No: 41017
Nα-Fmoc-N(im)-trityl-L-histidine, CAS: 109425-51-6, MW: 619.71, Formula: C40H33N3O4
Catalog No: 41017
Nα-Fmoc-N(im)-trityl-L-histidine, CAS: 109425-51-6, MW: 619.71, Formula: C40H33N3O4

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Nα-Fmoc-N(im)-trityl-L-histidine
Additional Information

Additional Information

Catalog Number 41017
CAS 109425-51-6
M.W. 619.71
Formula C40H33N3O4
IUPAC Name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
Synonym Nα-Fmoc-N(im)-trityl-L-histidine
Also Known As
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[tri(phenyl)methyl]imidazol-4-yl]propanoic acid
  • (2S)-2-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]-3-[1-[tri(phenyl)methyl]-4-imidazolyl]propanoic acid
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[tri(phenyl)methyl]imidazol-4-yl]propionic acid
  • 47639_FLUKA
  • Fmoc-His(Trt)-OH
  • Nalpha-Fmoc-N(im)-trityl-L-histidine
InChIKey XXMYDXUIZKNHDT-QNGWXLTQSA-N
InChI InChI=1S/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-43(27-41-31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/t37-/m0/s1
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)C[C@@H](C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57
Cited Uses

Details

1. Murugan RN et al, "De Novo Design and Synthesis of Ultra-Short Peptidomimetic Antibiotics Having Dual Antimicrobial and Anti-Inflammatory Activities", PLoS ONE, 8(11) pp.e80025 ().
2. Wang W et al, "Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia-reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues", Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2(4) pp.e000249 ().
3. Sani MA et al, "Maculatin 1.1 Disrupts Staphylococcus aureus Lipid Membranes via a Pore Mechanism", Antimicrobial Agents and Chemotherapy, 57(8) pp.3593-3600 (2013 Aug).
4. BÄ…chor R et al, "New method of peptide cleavage based on Edman degradation", Molecular Diversity, 17(3) pp.605-611 (2013 Aug).
5. Neupane KP et al, "Macrocyclization of the ATCUN Motif Controls Metal Binding and Catalysis", Inorganic chemistry, 52(5) pp.2729-2735 (2013 Mar 4).
6. Li Y et al, "18F-click labeling of a bombesin antagonist with an alkyne-18F-ArBF3 -: in vivo PET imaging of tumors expressing the GRP-receptor", American Journal of Nuclear Medicine and Molecular Imaging, 3(1) pp.57-70 ().
7. Rothbart SB et al, "Peptide Microarrays to Interrogate the Histone Code", Methods in enzymology, 512() pp.107-135 (2012).
8. Dong S et al, "Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain", Israel journal of chemistry, 51(8-9) pp.968-976 (2011 Nov).
9. Mahto SK et al, "A Reversible Protection Strategy to Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach", Chembiochem : a European journal of chemical biology, 12(16) pp.2488-2494 (2011 Nov 4).
10. Aggarwal S et al, "[DLys6]-LHRH-Curcumin Conjugate Inhibits Pancreatic Cancer Cell Growth in vitro and in vivo", International journal of cancer. Journal international du cancer, 129(7) pp.1611-1623 (2011 Oct 1).
11. Singh A et al, "Incorporation of a Bio-Active Reverse-Turn Heterocycle into a Peptide Template Using Solid-Phase Synthesis to Probe Melanocortin Receptor Selectivity and Ligand Conformations by 2D 1H NMR", Journal of medicinal chemistry, 54(5) pp.1379-1390 (2011 Mar 10).
12. Olsen AG et al, "A novel pseudo-complementary PNA G-C base pair", Artificial DNA, PNA & XNA, 2(1) pp.33-37 (2011).
13. Doedens L et al, "Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity; pharmacological and conformational studies", Journal of the American Chemical Society, 132(23) pp.8115-8128 (2010 Jun 16).
14. Karch F et al, "Synthesis of glycosylated ?3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues", Beilstein Journal of Organic Chemistry, 6() pp.47 ().
15. Kaushansky A et al, "Quantifying protein-protein interactions in high throughput using protein domain microarrays", Nature protocols, 5(4) pp.773-790 (2010).
16. Ohashi N et al, "Synthesis of protein kinase C? C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding", Journal of peptide science : an official publication of the European Peptide Society, 15(10) pp.642-646 (2009 Oct).
17. Qu H et al, "Substitution of Arginine with Proline and Proline Derivatives in Melanocyte-Stimulating Hormones Leads to Selectivity for Human Melanocortin 4 Receptor", Journal of medicinal chemistry, 52(12) pp.3627-3635 (2009 Jun 25).
18. Harris KS et al, "Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning", The Journal of Biological Chemistry, 284(14) pp.9361-9371 (2009 Apr 3).
19. Schneider EL et al, "Positional Scanning Synthetic Combinatorial Libraries for Substrate Profiling", Methods in molecular biology (Clifton, N.J.), 539() pp.59-78 (2009).
20. Boonyarattanakalin S et al, "A Synthetic Mimic of Human Fc Receptors: Defined Chemical Modification of Cell Surfaces Enables Efficient Endocytic Uptake of Human Immunoglobulin-G", Journal of the American Chemical Society, 128(35) pp.11463-11470 (2006 Sep 6).
21. Hu J et al, "Histidines, heart of the hydrogen ion channel from influenza A virus: Toward an understanding of conductance and proton selectivity", Proceedings of the National Academy of Sciences of the United States of America, 103(18) pp.6865-6870 (2006 May 2).
22. Halpin DR et al, "DNA Display III. Solid-Phase Organic Synthesis on Unprotected DNA", PLoS Biology, 2(7) pp.e175 (2004 Jul).
23. Gault VA et al, "Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.", Biochemical Journal, 367(Pt 3) pp.913-920 (2002 Nov 1).
24. Harris JL et al, "Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries", Proceedings of the National Academy of Sciences of the United States of America, 97(14) pp.7754-7759 (2000 Jul 5).
25. Meldal M et al, "Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.", Proceedings of the National Academy of Sciences of the United States of America, 91(8) pp.3314-3318 (1994 Apr 12).
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