Peptides & Peptide Synthesis Products

Rink Amide MBHA Resin

Rink Amide MBHA Resin
$25.00
$25.00
Rink Amide MBHA Resin, Catalog No: 52002
4-(2′,4′-Dimethoxyphenyl-Fmocaminomethyl) -phenoxyacetamidomethylbenzhydryl amine resin
100-200 mesh, 0.3-0.8 mMol/g
Catalog No: 52002
4-(2′,4′-Dimethoxyphenyl-Fmocaminomethyl) -phenoxyacetamidomethylbenzhydryl amine resin
100-200 mesh, 0.3-0.8 mMol/g

* Required Fields

Description

Details

Rink Amide MBHA Resin

This resin is less acid sensitive than Rink Amide resin because the benzhydrylamine linker is joined to the support through an electron-withdrawing acetamido spacer [1]. Normally the product is detached from the resin using 95% TFA in DCM plus scavengers as required by the composition of the substrate [1, 2]. It is also useful for preparing peptides. Boussard, Cyrille et al. has reported that synthesis of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin [3].

[1] Bernatowicz, M. S., Daniel, S. B., Koster, H., Tetrahedron Lett., 1989, 30, 4645

[2] M. Lebl, et al., J. Comb. Chem., 1999, 1, 474

[3] Boussard, Cyrille, et al., European Journal of Medicinal Chemistry, 2002, 37(11), pp, 883-890

Additional Information

Additional Information

Catalog Number 52002
Synonym 4-(2′,4′-Dimethoxyphenyl-Fmocaminomethyl) -phenoxyacetamidomethylbenzhydryl amine resin
Also Known As No
Mesh Size 100-200
Substitution (mMol/g) 0.3-0.8
Cited Uses

Details

1. Reuven EM et al, "The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses", PLoS Pathogens, 10(8) pp.e1004248 ().
2. Kreisig T et al, "His-tag protein monitoring by a fast mix-and-measure immunoassay", Scientific Reports, 4() pp.5613 ().
3. Klug YA et al, "Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site", Biochemical Journal, 461(Pt 2) pp.213-222 (2014 Jul 15).
4. Accardo A et al, "Self-assembled or mixed peptide amphiphile micelles from Herpes simplex virus glycoproteins as potential immunomodulatory treatment", International Journal of Nanomedicine, 9() pp.2137-2148 ().
5. Guo Y et al, "PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials", PLoS ONE, 9(4) pp.e95406 ().
6. Christie MP et al, "A Drug Delivery Strategy: Binding Enkephalin to Asialoglycoprotein Receptor by Enzymatic Galactosylation", PLoS ONE, 9(4) pp.e95024 ().
7. Schreier VN et al, "Protein Expression Profile of HT-29 Human Colon Cancer Cells after Treatment with a Cytotoxic Daunorubicin-GnRH-III Derivative Bioconjugate", PLoS ONE, 9(4) pp.e94041 ().
8. Krantz A et al, "Site-specific Labeling of a Protein Lysine Residue By Novel Kinetic Labeling Combinatorial Libraries", Computational and Structural Biotechnology Journal, 9() pp.e201403001 ().
9. Huang W et al, "Learning from Host-Defense Peptides: Cationic, Amphipathic Peptoids with Potent Anticancer Activity", PLoS ONE, 9(2) pp.e90397 ().
10. Mota A et al, "Human Bone Marrow Mesenchymal Stem Cell Behaviors on PCL/Gelatin Nanofibrous Scaffolds Modified with A Collagen IV-Derived RGD-Containing Peptide", Cell Journal (Yakhteh), 16(1) pp.1-10 (2014).
11. Newcomb CJ et al, "Cell death versus cell survival instructed by supramolecular cohesion of nanostructures", Nature communications, 5() pp.3321 (2014).
12. Zhang H et al, "Dual-acting stapled peptides target both HIV-1 entry and assembly", Retrovirology, 10() pp.136 ().
13. Kurth F et al, "Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes", PLoS ONE, 8(11) pp.e80210 ().
14. Cantisani M et al, "Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish", Antimicrobial Agents and Chemotherapy, 57(11) pp.5665-5673 (2013 Nov).
15. Leung CY et al, "Crystalline polymorphism induced by charge regulation in ionic membranes", Proceedings of the National Academy of Sciences of the United States of America, 110(41) pp.16309-16314 (2013 Oct 8).
16. Premkumar L et al, "Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases", Acta Crystallographica Section D: Biological Crystallography, 69(Pt 10) pp.1981-1994 (2013 Oct 1).
17. Tao K et al, "Short peptide-directed synthesis of one-dimensional platinum nanostructures with controllable morphologies", Scientific Reports, 3() pp.2565 ().
18. Taraban MB et al, "Split of Chiral Degeneracy in Mechanical and Structural Properties of Oligopeptide-Polysaccharide Biomaterials", Biomacromolecules, 14(9) pp.10.1021/bm4008309 (2013 Sep 9).
19. Kamadurai HB et al, "Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3", eLife, 2() pp.e00828 ().
20. Ceylan H et al, "Size-controlled conformal nanofabrication of biotemplated three-dimensional TiO2 and ZnO nanonetworks", Scientific Reports, 3() pp.2306 ().
21. Leight JL et al, "Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate", Biomaterials, 34(30) pp.7344-7352 (2013 Oct).
22. Nix MA et al, "Molecular and Functional Analysis of Human ?-Defensin 3 Action at Melanocortin Receptors", Chemistry & biology, 20(6) pp.784-795 (2013 Jun 20).
23. Kumar B et al, "Dynamics of Physical Interaction between HIV-1 Nef and ASK1: Identifying the Interacting Motif(S)", PLoS ONE, 8(6) pp.e67586 ().
24. Srivastava S et al, "Introduction of a Lysine Residue Promotes Aggregation of Temporin L in Lipopolysaccharides and Augmentation of Its Antiendotoxin Property", Antimicrobial Agents and Chemotherapy, 57(6) pp.2457-2466 (2013 Jun).
25. Prokai-Tatrai K et al, "Design and Exploratory Neuropharmacological Evaluation of Novel Thyrotropin-Releasing Hormone Analogs and Their Brain-Targeting Bioprecursor Prodrugs", Pharmaceutics, 5(2) pp.318-328 ().
Reviews
cr